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Martin Biel

Prof. Dr. Martin Biel

Regular member MCN, GSN core faculty

Responsibilities

Chair of Pharmacology

Contact

Ludwig-Maximilians-University Munich
Department of Pharmacy
Center for Drug Research
Butenandtstr. 7, Building C
D-81377 Munich

Phone: +49 (0)89 / 2180-77327
Fax: +49 (0)89 / 2180-77326

Website: http://www.cup.uni-muenchen.de/dept/ph/pharmakologie/biel.php
Website: http://www.pharmacology.cup.uni-muenchen.de/index.html

Further Information

Research focus: Physiological and pathophysiological role of ion channels, intracellular ion channels, ion channels in neuronal circuit function, diseases of the retina, gene therapy approaches

Key words: Ion channels, retina, gene therapy, neuronal circuits

GSN students: Saskia Spahn, Lisa Riedmayr

Selected publications:

Becirovic E, Böhm S, Nguyen O, Riedmayr LM, Koch MA, Schulze E, Kohl S, Borsch O, Santos-Ferreira T, Ader M, Michalakis S, Biel M (2016) In vivo analysis of disease-associated point mutations unveils profound differences in mRNA splicing of peripherin-2 in rod and cone photoreceptors. PLOS Genetics 12:e1005811. doi: 10.1371/journal.pgen.1005811

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA (2015) Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment. Science 347, 995-998

Grimm C, Holdt LM, Chen CC, Hassan, H, Jörs S Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Müller C, Spahn S, Castonguay J, Luber CA, Moser M, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C (2014) High Susceptibility to Fatty Liver Disease in Two-pore Channel 2 Deficient Mice. Nat Commun 5:4699. doi:10.1038/ncomms

Fenske S, Mader R, Scharr A, Paparizos C, Cao-Ehlker X, Michalakis S, Shaltiel L, Weidinger M, Stieber J, Feil S, Feil R, Schneider A, Hofmann F, Wahl-Schott CA, Biel M (2011) HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res 109:1015-1023

Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature 393:587-591.