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Martin Dichgans

Prof. Dr. Martin Dichgans

Regular member MCN, GSN Scientific Board member

Responsibilities

Director, Institute for Stroke and Dementia Research (ISD)

Contact

Institute for Stroke and Dementia Research (ISD)
Ludwig-Maximilians-University Munich, Medical Center
Feodor-Lynen-Stra├če 17
D-81377 Munich

Phone: +49 (0)89 4400 - 46019
Fax: +49 (0)89 4400 - 46010

Website: http://research.isd-muc.de/

Further Information

Research focus: Stroke, genetics of stroke, dementia; vascular dementia, neuroimaging, migraine

Key words: Clinical neuroscience, neurogenetics

Current GSN students: Manuel Lehm, Steffen Tiedt

Selected publications:

Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.; Stroke Genetics Network (SiGN).; International Stroke Genetics Consortium (ISGC) (Dichgans M).. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol. (IF 23,5)

Dichgans M, Wardlaw J, Smith E, Zietemann V, ..., Düring M, ..., Malik R, ..., Yang YH. METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer‘s & dementia (IF 11,6)

Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M. Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke. (2015)

Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, Dichgans M. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proc Natl Acad Sci U S A. (2014)

Dichgans M, Malik R, ..., Farrall M, Schunkert H; ... Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. (2014)

Malik R, ..., Mitchell BD, Rosand J, Meschia JF, Levi C, Rothwell PM, ..., Dichgans M; Wellcome Trust Case Control Consortium 2. Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke. (2014)

Opherk C, Gonik M, Duering M, Malik R, Jouvent E, Hervé D, ..., Rosand J, Chabriat H, Dichgans M. Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL. Stroke. (2014)

Wardlaw JM*, Smith EE*, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O’Brien JT, Barkhof F, Benavente OR, Black S, Brayne C, Breteler M, Chabriat H, DeCarli C, de Leeuw FE, Doubal F, Duering M, Fox N, Greenberg S, Hachinski V, Kliniman I, Mok V, van Oostenbrugge R, Pantoni L, Speck O, Stephan BCM, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB and Dichgans M*. (2013) Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration: A united approach. Lancet Neurol. (*equally contributing)

Wardlaw JM, Smith C and Dichgans M. (2013) Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 12(5): 483-97.

Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, Pozo-Rosich P, Winsvold B, Nyholt DR, van Oosterhout WP, Artto V, Todt U, Hämäläinen E, Fernández-Morales J, Louter MA, Kaunisto MA, Schoenen J, Raitakari O, Lehtimäki T, Vila-Pueyo M, Göbel H, Wichmann E, Sintas C, Uitterlinden AG, Hofman A, Rivadeneira F, Heinze A, Tronvik E, van Duijn CM, Kaprio J, Cormand B, Wessman M, Frants RR, Meitinger T, Müller-Myhsok B, Zwart JA, Färkkilä M, Macaya A, Ferrari MD, Kubisch C, Palotie A, Dichgans M and van den Maagdenberg AM; International Headache Genetics Consortium. (2012) Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet. 44(7): 777-82.

Duering M, Zieren N, Hervé D, Jouvent E, Reyes S, Peters N, Pachai C, Opherk C, Chabriat H and Dichgans M. (2011) Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL. Brain 134(8): 2366-75.

Dichgans M, Freilinger F, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, Ferrari M, Herzog J, van den Maagdenberg AMJM, Pusch M and Strom TM. (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 366: 371-377.