Prof. Dr. Günter Höglinger

Brief research description: The focus of my scientific work is the tight connection of patient-related research with basic research, with the aim ot develop new diagnostic and therapeutic concepts. We use both information from clinical research to develop and improve disease models (bedside to bench), and new concepts from preclinical research to be validated in human patients (bench to bedside). We concentrate our research on diseases defined by pathological propagation and aggregation of the alpha-synuclein (e.g. Parkinson’s disease, Lewy body dementia, multisystem atrophy) and the tau protein (e.g. forms of frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration). Both alpha-synuclein and tau are considered as proteinaceous infectious particles (prions), which chronically and progressively infect brain cells. Susceptibility and resilience factors are a focus of our research to develop novel therapies.