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Maria Robles

Prof. Dr. Maria Robles

MCN regular member, GSN associate faculty


Head of Systems Chronobiology


Ludwig-Maximilians-Universität München
Institute of Medical Psychology


Further Information

Keywords: Circadian, sleep, proteomics, mass spectrometry

Research description: We are applying mass spectrometry-based quantitative proteomics and phosphoproteomics to understand circadian- and sleep-driven processes in diverse mammalian tissues. In brain we are investigating how molecular processes are shaped across the day in specific brain areas as well as in the synaptic compartment and how they are affected by circadian and/or sleep disruption.

Selected publications:

1. Hansen FM, Tanzer MC, Brüning F, Bludau I, Stafford C, Schulman BA, Robles MS*, Karayel O*, Mann M*. (2021) Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nat Commun. Jan 11;12(1):254. *co-corresponding author doi: 10.1038/s41467-020-20509-1

2. Brüning F, Noya SB, Bange T, Koutsouli S, Rudolph JD, Tyagarajan SK, Cox J, Mann M, Brown SA*, Robles MS*. (2019) Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. Oct 11;366(6462). *co-corresponding author doi: 10.1126/science.aav3617

3. Noya SB, Colameo D, Brüning F, Spinnler A, Mircsof D, Opitz L, Mann M, Tyagarajan SK*, Robles MS*, Brown SA*. (2019) The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science. Oct 11;366(6462). *co-corresponding author doi: 10.1126/science.aav2642

4. Robles MS, Humphrey SJ and Mann M. (2017) Central role of phosphorylation in the circadian control of liver metabolism. Cell Metab Jan 10;25(1):118-127 doi: 10.1016/j.cmet.2016.10.004

5. Robles MS, Cox J, Mann M. (2014) In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS Genet. Jan; 10(1): e1004047 doi: 10.1371/journal.pgen.1004047