Prof. Dr. Rainer Landgraf

HAB/LAB mice as an animal model to simulate anxiety disorders and comorbid depression

Extinction of learned fear and acoustic startle response

Social discrimination test

Neuropeptide S effects

Combined expression and genotypic approaches to identify candidate genes and biomarkers of trait anxiety

Causal associations: F2 panel and clinical samples

Interaction between environmental epigenomics and genetic predisposition in shaping the anxiety phenotype of HAB vs. LAB mice

Biomarker identification in HAB mice

Biomarker Identification in a Mouse Model for Trait Anxiety

Functional Manganese-enhanced MRI

Towards in vivo functions of Urocortin 2 and Urocortin 3 using loss- and gain-of-function mouse models

Translocator protein (18 kDa) as a target for anxiolytics without benzodiazepine inherent side effects

High-speed imaging of neuronal network activity in brain regions relevant for depression and anxiety

Electrophysiological correlates of anxiety- and depression-like behaviors

Comparison of sleep architectures in mouse models of anxiety/depression and chronic stress

Selected publications:

Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, Heck A, Pfister H, Zimmermann P, Lieb R, Pütz B, Uhr M, Weber P, Deussing JM, Gonic M, Bunck M, Keßler MS, Frank E, Hohoff C, Domschke K, Krakowitzky P, Maier W, Bandelow B, Jacob C, Deckert J, Schreiber S, Strohmaier J, Nöthen M, Cichon S, Rietschel M, Bettecken T, Keck ME, Landgraf R, Müller-Myhsok B, Holsboer F and Binder EB. (2011) TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Mol. Psychiatry 16: 647-663.

Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M and Yassouridis A. (2011) Sleep disturbances in highly stress reactive mice: Modeling endophenotypes of major depression. BMC Neurosci. 12, 29.

Gaburro S, Stiedl O, Giusti P, Sartori SB, Landgraf R and Singewald N. (2011) A mouse model of high trait anxiety shows reduced heart-rate variability that can be reversed by anxiolytic drug treatment. Int. J. Neuropsychopharmacol. 15: 1-15.

Kessler MS, Bosch OJ, Bunck M, Landgraf R and Neumann ID (2011). Maternal care differs in mice bred for high versus low trait anxiety: impact of brain vasopressin and cross-fostering. Soc. Neurosci. 6: 156-168.

Tasan RO, Bukovac A, Peterschmitt YN, Sartori SB, Landgraf R, Singewald N and Sperk G. (2011) Altered GABA transmission in a mouse model of increased trait anxiety. Neuroscience 183: 71-80.