Responsibilities
Head of the Laboratory of Neurodegenerative Disease Research (Haass Lab)
Speaker of the Collaborative Research Center 596
Member of the Center for Integrated Protein Science Munich
Speaker of the German Center for Neurodegenerative Diseases (DZNE) - Munich
Contact
German Center for Neurodegenerative Diseases (DZNE)
Feodor-Lynenstr. 17,
81337 München
Phone:
089/ 4400 46549
Fax:
089/ 4400 46546
Email:
christian.haass@med.uni-muenchen.de
Website:
http://www.biochemie.abi.med.uni-muenchen.de/about/staff/professors/haass/index.html
Website:
http://www.dzne.de/en/centers/munich/research-groups/haass.html
Further Information
Research focus: Cellular neurobiology, molecular neurobiology
Key words: Alzheimer's and Parkinson's disease, ß-amyloid precursor protein (ßAPP), human cells, yeast, C. elegans, zebrafish, transgenic mouse models, BACE1 and BACE, secretase complex components (Presenilin, Aph-1, Nicastrin, and Pen-2), parkin and DJ-1, intramembraneous cleavage
- Current: Marvin Reich
- Graduated: Dr. Joanna McCarter, Dr. Sabine Liebscher, Dr. Xianyuan Xiang
Selected publications:
Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann KH, Haass C and Steiner H. (2011) Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. J Biol Chem. 286(17):15240-51.
Fleck D, Garratt AN, Haass C and Willem M. (2011) BACE1 Dependent Neuregulin Proteolysis. Curr Alzheimer Res. 2011 May 23.
Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B and Haass C. (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci. 27(45): 12413-8.
Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C and Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314(5799): 664-6.
Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB and Haass C. (2006) A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol. 8(8): 894-6.