Responsibilities
Director of Institute of Clinical Neuroimmunology
Biomedical Center and University Hospital
Contact
Institute of Clinical Neuroimmunology
Phone:
++49 89 2180 71660
Email:
Martin.Kerschensteiner@med.uni-muenchen.de
Website:
http://ini.klinikum.uni-muenchen.de
Further Information
Keywords: multiple sclerosis, neuroinflammation, axon degeneration, synapse loss, microglia
Brief research description: In multiple sclerosis infiltrating immune cells damage resident cells of the nervous system such as neurons and oligodendrocytes. This structural damage is responsible for the irreversible functional deficits in patients with multiple sclerosis. The aim of our work is to better understand how immune cells cause nervous system damage and use this knowledge to develop novel treatment strategies that limit tissue damage in multiple sclerosis.
Current and graduated GSN students: Daniela Beckmann, Emily Melisa Ullrich Gavilanes, Dr. Marta Wesolowski, Dr. Aleksandra Mezydlo, Clara de la Rosa del Val
Selected publications:
Witte ME, Schumacher AM, Mahler CF, Bewersforf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M (2019) Calcium influx through plasma-membrane nanopores drives axon degeneration in a model of multiple sclerosis. Neuron 101, 615-624
Locatelli G, Theodorou D, Kendirli A, Jordão MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M (2018) Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nature Neuroscience 21, 1196-1208
Romanelli E., Merkler D., Mezydlo M., Weil M.T., Weber M.S., Nikic I., Potz S., Meinl E., Matznick F.E.H., Kreutzfeldt M., Ghanem A., Conzelmann K.K., Metz I., Brück W., Routh M., Simons M., Bishop D., Misgeld T. & Kerschensteiner M. (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nature Communications, 13275
Sorbara C.D., Wagner N.E., Ladwig A., Nikic I., Merkler D., Kleele T., Marinkovic P., Naumann R., Godinho L., Bareyre F.M., Bishop D., Misgeld T. & Kerschensteiner M. (2014) Pervasive axonal transport deficits in multiple sclerosis models. Neuron 84: 1183-1190
Breckwoldt M.O., Pfister F.M., Bradley P.M., Marinkovic P., Williams P.R., Brill M.S., Plomer B., Schmalz A., St Clair D.K., Naumann R., Griesbeck O., Schwarzländer M., Godinho L., Bareyre F.M., Dick T.P., Kerschensteiner M (*) & Misgeld T (*).(*co-senior author and corresponding author) (2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nature Medicine 20: 555-560
Nikic I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeld M, Bareyre FM, Brück W, Bishop D, Misgeld T and Kerschensteiner M. (2011) A reversible form of axon damage in multiple sclerosis and its animal model. Nature Medicine 17: 495-9