Munich Center for NeuroSciences - Brain and Mind
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Martin Kerschensteiner

Prof. Dr. Martin Kerschensteiner

GSN full member, regular member MCN

Responsibilities

Director of Institute of Clinical Neuroimmunology
Biomedical Center and University Hospital

Contact

LMU Biomedical Center
Institute of Clinical Neuroimmunology

Phone: ++49 89 2180 71660

Website: http://ini.klinikum.uni-muenchen.de

Further Information

Keywords: multiple sclerosis, neuroinflammation, axon degeneration, synapse loss, microglia

Brief research description: In multiple sclerosis infiltrating immune cells damage resident cells of the nervous system such as neurons and oligodendrocytes. This structural damage is responsible for the irreversible functional deficits in patients with multiple sclerosis. The aim of our work is to better understand how immune cells cause nervous system damage and use this knowledge to develop novel treatment strategies that limit tissue damage in multiple sclerosis. 

Current and graduated GSN students: Daniela Beckmann, Emily Melisa Ullrich GavilanesDr. Marta Wesolowski, Dr. Aleksandra Mezydlo, Clara de la Rosa del Val

Selected publications:

Witte ME, Schumacher AM, Mahler CF, Bewersforf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M (2019) Calcium influx through plasma-membrane nanopores drives axon degeneration in a model of multiple sclerosis. Neuron 101, 615-624

Locatelli G, Theodorou D, Kendirli A, Jordão MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M (2018) Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nature Neuroscience 21, 1196-1208

Romanelli E., Merkler D., Mezydlo M., Weil M.T., Weber M.S., Nikic I., Potz S., Meinl E., Matznick F.E.H., Kreutzfeldt M., Ghanem A., Conzelmann K.K., Metz I., Brück W., Routh M., Simons M., Bishop D., Misgeld T. & Kerschensteiner M. (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nature Communications, 13275

Sorbara C.D., Wagner N.E., Ladwig A., Nikic I., Merkler D., Kleele T., Marinkovic P., Naumann R., Godinho L., Bareyre F.M., Bishop D., Misgeld T. & Kerschensteiner M. (2014) Pervasive axonal transport deficits in multiple sclerosis models. Neuron 84: 1183-1190

Breckwoldt M.O., Pfister F.M., Bradley P.M., Marinkovic P., Williams P.R., Brill M.S., Plomer B., Schmalz A., St Clair D.K., Naumann R., Griesbeck O., Schwarzländer M., Godinho L., Bareyre F.M., Dick T.P., Kerschensteiner M (*) & Misgeld T (*).(*co-senior author and corresponding author) (2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nature Medicine 20: 555-560

Nikic I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeld M, Bareyre FM, Brück W, Bishop D, Misgeld T and Kerschensteiner M. (2011) A reversible form of axon damage in multiple sclerosis and its animal model. Nature Medicine 17: 495-9