Responsibilities
Director "Institute of Clinical Neuroimmunology"
Contact
Biomedical Center
Institute of Clinical Neuroimmunology
Großhaderner Strasse 9
82152 Planegg-Martinsried
+49 (0) 89 2180 71660 (J. Marks, Sekretariat)
+49 (0) 89 2180 71658 (A. Schmalz, Koordination)
Phone:
+49 (0)89 / 2180 71662
Fax:
+49 (0)89 / 2180-71811
Email:
Martin.Kerschensteiner@med.uni-muenchen.de
Website:
http://www.bmc.med.lmu.de
Website:
http://www.neuroimmunology-munich.de
Further Information
Research focus: Pathogenesis of neuroinflammatory tissue damage, in vivo microscopy of axonal pathology, development of neuroprotective treatment strategies
Key words: Multiple sclerosis, Neuroimmunology, Axonal Degeneration, In vivo microscopy
- Current GSN students: Daniela Beckmann, Emily Melisa Ullrich Gavilanes
- Graduated GSN students: Dr. Marta Wesolowski, Dr. Aleksandra Mezydlo
Selected publications:
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Locatelli G, Theodorou D, Kendirli A, Jordão MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M. Nat Neurosci. 2018 Sep;21(9):1196-1208. doi: 10.1038/s41593-018-0212-3. Epub 2018 Aug 20. PMID: 30127427
Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Witte ME, Schumacher AM, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M. Neuron. 2019 Feb 20;101(4):615-624.e5. doi: 10.1016/j.neuron.2018.12.023. Epub 2019 Jan 24. PMID: 30686733
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M. Nat Neurosci. 2021 Jan 25. doi: 10.1038/s41593-020-00780-7. Online ahead of print. PMID: 33495636
Romanelli E., Merkler D., Mezydlo M., Weil M.T., Weber M.S., Nikic I., Potz S., Meinl E., Matznick F.E.H., Kreutzfeldt M., Ghanem A., Conzelmann K.K., Metz I., Brück W., Routh M., Simons M., Bishop D., Misgeld T. & Kerschensteiner M. (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nature Communications, 13275
Sorbara C.D., Wagner N.E., Ladwig A., Nikic I., Merkler D., Kleele T., Marinkovic P., Naumann R., Godinho L., Bareyre F.M., Bishop D., Misgeld T. & Kerschensteiner M. (2014) Pervasive axonal transport deficits in multiple sclerosis models. Neuron 84: 1183-1190
Breckwoldt M.O., Pfister F.M., Bradley P.M., Marinkovic P., Williams P.R., Brill M.S., Plomer B., Schmalz A., St Clair D.K., Naumann R., Griesbeck O., Schwarzländer M., Godinho L., Bareyre F.M., Dick T.P., Kerschensteiner M (*) & Misgeld T (*).(*co-senior author and corresponding author) (2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nature Medicine 20: 555-560
Nikic I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeld M, Bareyre FM, Brück W, Bishop D, Misgeld T and Kerschensteiner M. (2011) A reversible form of axon damage in multiple sclerosis and its animal model. Nature Medicine 17: 495-9.
Bishop D., Nikic I., Brinkoetter M., Knecht S., Potz S., Kerschensteiner M.(*), Misgeld T.(*, co–senior author and corresponding author) (2011) Near-infrared branding efficiently correlates light and electron microscopy. Nature Methods 8: 568-570