Prof. Dr. med. Thomas Misgeld

Research focus: Cellular Neuroscience

Key words: In vivo imaging, two-photon imaging, axon degeneration, spinal cord, multiple sclerosis, spinal cord injury, motor axons, neuromuscular junction, mice, zebrafish

Current GSN students:  Selin Kenet, Antoneta Gavoci, Pui Shee Lee, Eleni Petridou

Graduated GSN students: Dr. Caroline Fecher

Selected publications: 

Brill M.S., Kleele T., Ruschkies L., Wang M., Marahori N.A., Reuter M., Hausrat T.J., Weigand E., Fisher M., Ahles A., Engelhardt S., Bishop D.L., Kneussel M. & Misgeld T. (2016) Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination. Neuron, 92:845-56.

Romanelli E., Merkler D, Mezydlo A., Weil M.T., Weber M.S., Nikić I., Potz S., Meinl E., Matznick F.E.H., Kreutzfeldt M., Ghanem A., Conzelmann K.K., Metz I., Brück W., Routh M., Simons M., Bishop D., Misgeld T.* & Kerschensteiner M. (2016) Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its model. Nature Communications, 7:13275. (* equal senior author)

Plucińska G. & Misgeld T. (2016) Imaging of neuronal mitochondria in situ. Current Opinion in Neurobiology 39:152-63.

Herwerth M., Kalluri S.R., Srivastava R., Kleele T., Kenet S., Illes Z., Merkler D., Bennett J.L., Misgeld T.* & Hemmer B. (2016) In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Annals of Neurology eop (* equal senior author)

Sorbara, C.D., Wagner, N.E., Ladwig, A., Nikic, I., Merkler, D., Kleele, T., Marinković, P., Godinho, L., Bareyre, F.M., Bishop, D., Misgeld, T.* and Kerschensteiner M.* (2014). Pervasive axonal transport deficits in multiple sclerosis models. Neuron. 84:1183-90. (* equal senior author)

Williams, P.R., Marincu, B.N., Sorbara, C.D., Mahler, C.F., Schumacher, A.-M., Griesbeck, O., Kerschensteiner, M. and Misgeld T.* (2014). A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat. Commun. 5:5683.

Breckwoldt, M.O., Pfister, F., Bradley, P.M., Marinković, P., Williams, P.W., Brill, M.S., Plomer, P., Schmalz, A., St. Clair, D.K., Naumann, R., Griesbeck, O., Schwarzländer, M., Godinho, L., Bareyre, F.M., Dick, T.P., Kerschensteiner, M. and Misgeld, T. (2014). Multi-parametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat. Med. 20(5):555-560.

Kleele, T., Marinković, P., Wiliams, P.R., Brill, M., Stern S., Weigand, E.E., Engerer, P., Naumann, R., Hartmann, J., Karl, M.K., Bradke, F., Bishop, D., Herms, J., Konnerth, A., Kerschensteiner, M., Godinho, L. and Misgeld, T. (2014). Imaging of microtubular dynamics in intact mammalian axons. Nat. Commun. 5:4827.

Marinković, P., Reuter, M.S., Brill, M.S., Godinho, L., Kerschensteiner, M. and Misgeld, T. (2012). Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 109(11):4296-301.

Plucińska, G., Paquet, D., Hruscha, A., Godinho, L., Haass, C., Schmid, B. and Misgeld, T. (2012). In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. J. Neurosci. 32(46):16203-12.

Nikic, I., Merkler, D., Sorbara, C., Brinkoetter, M., Kreutzfeld, M., Bareyre, F.M., Brück, W., Bishop, D., Misgeld, T.* and Kerschensteiner, M.* (2011). A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat. Med. 17(4):495-499. (* equal senior author)

Bishop, D., Nikic, I., Brinkoetter, M., Knecht, S., Potz, S., Kerschensteiner, M., and Misgeld, T. (2011). NIRB – near infrared branding efficiently correlates light and electron microscopy. Nat. Methods 8(7):568-570.

Misgeld, T., Kerschensteiner, M., Bareyre, F.M., Burgess, R.W., and Lichtman, J.W. (2007). In vivo imaging axonal transport of mitochondria in mammals. Nat. Methods 4(7):559–561.

Kerschensteiner, M., Schwab, M.E., Lichtman, J.W., and Misgeld, T. (2005). In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat. Med. 11(5):572-577.