Prof. Dr. Angelika Harbauer

Primary research focus: Molecular & Developmental Neuroscience

Keywords: Mitochondria, RNA transport, local translation, neurodegeneration

Research methods: live cell imaging, biochemistry, molecular biology

Selected publications:

Schmidt, O.*, Harbauer, A.B.*, Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., and Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239. doi: 10.1016/j.cell.2010.12.015. (*equal contribution)

Harbauer, A.B., Opalińska, M., Herman, J.S., Rao, S., Guiard, B., Schmidt, O., Pfanner, N., and Meisinger, C. (2014) Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science, 346(6213), 1109–13.doi: 10.1126/science.1261253.

Kravic B., Harbauer A.B., Romanello V., Simeone L., Vögtle F.-N., Kaiser T., Straubinger M., Huraskin D. Böttcher M., Cerqua C., Martin E. D., Poveda-Huertes D., Buttgereit A., Rabalski A. J., Heuss, D., Rudolf R., Friedrich, O., Litchfield D., Marber M., Salviati L., Mougiakakos D., Neuhuber W., Sandri M., Meisinger C., Hashemolhosseini S. (2018) In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy, 14(2), 311-335. doi: 10.1080/15548627.2017.1403716.

Harbauer A.B. (2017) Mitochondrial health maintenance in axons. Biochem. Soc. Trans. 45, 1045–1052 doi: 10.1042/BST20170023

Harbauer, A. B.; Hees, J. T.; Wanderoy, S.; Segura, I.; Gibbs, W.; Cheng, Y.; Ordonez, M.; Cai, Z.; Cartoni, R.; Ashrafi, G. et al. (2022) Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron 110 (9), S. 1516 - 1531.e9 doi: 10.1016/j.neuron.2022.01.035