Dr. Stefanie Hauck

Primary research focus: Cellular & Systems Neuroscience

Second research focus: Biomedical Neuroscience

Keywords: quantitative proteomics, metabolomics, mass spectroemtry, neuroprotection, retinal degeneration

Research methods: Targeted and non-targeted metabolomics, lipidomics, quantitative proteomics (LC-MSMS based), interatome studies, extracellular matrix profiling, immunopeptidomics. Proximity extension asssays (PEA) by Olink, certified Olink Target96, Target48 and Explore platforms

Brief research description: Proteome-wide identification of disease mechanisms and neurodegenerative processes in retina and brain. Functional characterization of retinal Müller glial cells in health and disease. Development of gene activation strategies to counteract retinal degeneretion.

Current or graduated GSN students: Viktoria Split (PhD defense), Lew Kaplan (TAC)

Selected publications:

Kaplan L, Drexler C, Pfaller AM, Brenna S, Wunderlich KA, Dimitracopoulos A, Merl-Pham J, Perez M-T, Schlötzer-Schrehardt U, Enzmann V, Samardzija M, Puig B, Fuchs P, Franze K, Hauck SM, and Grosche A. Retinal regions shape human and murine Müller cell proteome profile and functionality. Glia. 2022 Nov 5. doi: 10.1002/glia.24283. Online ahead of print.

O’Neill AC, Uzbas F, Antognolli G, Merino F, Draganova K, Jäck A, Zhang S, Pedini G, Schessner J, Cramer K, Schepers A, Metzger F, Esgleas M, Smialowski P, Guerrini R, Falk S, Feederle R, Freytag S, Wang Z, Bahlo M, Jungmann R, Bagni C, Borner GHH, Robertson SP, Hauck SM and Götz M. Spatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs. Science. 2022 Jun 17;376(6599):eabf9088. doi: 10.1126/science.abf9088. Epub 2022 Jun 17. PMID: 35709258

Schmalen A, Lorenz l, Grosche A, Pauly D, Deeg CA and Hauck SM. Proteomic phenotyping of stimulated Mueller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity. Front Pharmacol. 2021 Oct 29;12:771571. doi: 10.3389/fphar.2021.771571. eCollection 2021.

Thomas J, Martinez-Reza MF, Thorwirth M, Zarb Y, Conzelmann K-K, Hauck SM, Grade S, Götz M. Excessive local host-graft connectivity in ageing and amyloid-loaded brain. Sci Adv. 2022 Jun 10;8(23):eabg9287. doi: 10.1126/sciadv.abg9287. Epub 2022 Jun 10. PMID: 35687689

Camargo Ortega G, Falk S, Johansson PA, Peyre E, Sahu S, Broix L, De Juan Romero C, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Merl-Pham J, Geerlof A, Feederle R, Shao W, Shi S-H, Hauck SM, Bradke F, Borrell V, Tiwary V, Huttner W, Wilsch-Bräuninger M, Nguyen L and Götz M. The centrosome protein Akna regulates neurogenesis via microtubule organization. Nature. 2019 Mar;567(7746):113-117. doi: 10.1038/s41586-019-0962-4.