PD Dr. Igor Yakushev

Research focus: I lead the research group “multimodal imaging of normal and pathological cognition”. Our ultimate aim is to understand the mechanisms of normal and pathological cognitive function. Herewiith, we rely on the concept of brain connectivity and apply neuroimaging methods such as positron emission tomography, structural, functional MRI, and diffusion weighted imaging.

Keywords: multimodal neuroimaging, molecular imaging, neurodegenerative disorders, biomarkers, brain connectivity, computational neuroimaging

Current GSN Students: Isabelle Ripp

Selected publications:

- Yakushev I, Ripp I, Wang M, Savio A, Schutte M, Lizarraga A, Bogdanovic B, Diehl-Schmid J, Hedderich DM, Grimmer T, Shi K. Mapping covariance in brain FDG uptake to structural connectivity. European Journal of Nuclear Medicine and Molecular Imaging 2022; in press. IF2020 9.2

- Ripp I, Wallenwein L, Wu Q, Emch M, Koch K, Cumming P, Yakushev I. Working memory task induced neural activation: a simultaneous PET/fMRI study. Neuroimage 2021; 15; 237: 118131. IF2020 6.6

- Ripp I, Stadhouders T, Savio A, Goldhardt O, Cabello J, Calhoun V, Riedl V, Hedderich D, Diehl-Schmid J, Grimmer T, Yakushev I. Integrity of neurocognitive networks in dementing disorders as measured with simultaneous PET/fMRI. Journal of Nuclear Medicine 2020; 61: 1341-1347. IF2020 10.1

- Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, … Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease. Molecular Psychiatry 2019; 26: 614-628. IF2019 12.4

- Guo T, Dukart J, Brendel M, Rominger A, Grimmer T, Yakushev I. Rate of beta-amyloid accumulation varies with baseline amyloid burden: implications for anti-amyloid drug trials. Alzheimer’s & Dementia 2018; 14: 1387-1396. Featured article. IF2018 14.4