PD Dr. Igor Yakushev

Research focus: I lead the research group “multimodal imaging of normal and pathological cognition”. Our ultimate aim is to understand the mechanisms of normal and pathological cognition. Herewith, we rely on the concept of brain connectivity and apply neuroimaging methods such as positron emission tomography, structural, functional MRI, and diffusion weighted imaging.

Keywords: molecular imaging, multimodal neuroimaging, neurodegenerative disorders, biomarkers, brain connectivity, computational neuroimaging

Current GSN Students: Dr. Isabelle Ripp

Selected publications:

- Voeglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, … Chrem P, Allegri R, Ringman JM, Yakushev I, Laske C, Jucker M, Hoeglinger G, Bateman RJ, Danek A, Levin J. Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer’s & Dementia 2022, in press. IF=16.7.

- Yakushev I, Ripp I, Wang M, Savio A, Schutte M, Lizarraga A, Bogdanovic B, Diehl-Schmid J, Hedderich DM, Grimmer T, Shi K. Mapping covariance in brain FDG uptake to structural connectivity. European Journal of Nuclear Medicine and Molecular Imaging 2022; 49:1288-1297. IF=10.1.

- Ripp I, Wallenwein L, Wu Q, Emch M, Koch K, Cumming P, Yakushev I. Working memory task induced neural activation: a simultaneous PET/fMRI study. Neuroimage 2021; 15; 237: 118131. IF=7.4.

- Ripp I, Stadhouders T, Savio A, Goldhardt O, Cabello J, Calhoun V, Riedl V, Hedderich D, Diehl-Schmid J, Grimmer T, Yakushev I. Integrity of neurocognitive networks in dementing disorders as measured with simultaneous PET/fMRI. Journal of Nuclear Medicine 2020; 61: 1341-1347. IF=10.1.

- Guo T, Dukart J, Brendel M, Rominger A, Grimmer T, Yakushev I. Rate of beta-amyloid accumulation varies with baseline amyloid burden: implications for anti-amyloid drug trials. Alzheimer’s & Dementia 2018; 14: 1387-1396. Featured article. IF=14.4.