PD Dr. Thomas Köglsperger

Research focus:

My clinical research focus is on investigating DBS (programming) in movement disor-ders such as Parkinson’s disease (PD), tremor or dystonia. My experimental research is focused on examining the molecular mechanism of PD. We apply a combination of patch-clamp electrophysiology, biochemistry and imaging to examine structural and functional alterations in PD. We have recently described a loss of the Fragile X Mental Retardation Protein (FMRP) in PD (Tan et al., 2019) and our current research focuses on investigating the specific cellular and molecular role of FMRP in PD pathology progres-sion. Another focus is the examination of novel miRNA biomarkers in PD, where we are particularly interested in studying the GI tract as a potential source of novel PD bi-omarkers. In addition, we have a particular interest in studying the role of extracellular vesicles (EVs) in neurodegenerative conditions.

Key words: Deep Brain Stimulation (DBS); Parkinson’s Disease (PD); Fragile X Syndrome (FXS); Patch-Clamp Electrophysiology; Extracellular Vesicles (EVs).

Selected publications:

Kumar R, Tang Q, Müller SA, Gao P, Mahlstedt D, Zampagni S, Tan Y, Klingl A, Bötzel K, Lichtenthaler SF, Höglinger GU, Koeglsperger T (2020) Fibroblast Growth Factor 2‐Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons. Advanced Science 115:1902372–15. doi: 10.1002/advs.201902372

Tan Y, Sgobio C, Arzberger T, Machleid F, Tang Q, Findeis E, Tost J, Chakroun T, Gao P, Höllerhage M, Bötzel K, Herms J, Höglinger G, Koeglsperger T (2019) Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease. Acta Neuropathologica 1–27. doi: 10.1007/s00401-019-02099-5

Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL (2014) Identification of a unique TGF-β-dependent molecular and func-tional signature in microglia. Nature Neuroscience 17:131–143. doi: 10.1038/nn.3599

Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL (2013) Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia 61:985–1002. doi: 10.1002/glia.22490

Koeglsperger T, Palleis C, Hell F, Mehrkens JH, Bötzel K (2019) Deep Brain Stimulation Pro-gramming for Movement Disorders: Current Concepts and Evidence-Based Strategies. Fron-tiers in Neurology 10:410. doi: 10.3389/fneur.2019.00410