Responsibilities
Professor of Molecular Neurobiology
Contact
Technical University Munich
German Center for Neurodegenerative Diseases (DZNE)
Feodor-Lynen-Straße 17
81377 Munich
Germany
Phone:
+49 (0) 89 4400 46495
Email:
mikael.simons@dzne.de
Website:
http://www.neuroscience.med.tum.de/index.php?id=5
Website:
http://www.mikael-simons-lab.de
Further Information
Research focus: Myelin biogenesis, Regeneration in the CNS, Neurodegeneration
Current GSN students: Liliana Pedro, Vini Tiwari, Garyfallia Gouna, Tuğberk Kaya
Graduated GSN students: Dr. Mar Bosch Queralt
Selected publications:
Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M (2016) Age-related myelin degradation burdens microglia clearance function during aging. Nature Neurosci, 9:995-8.
Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N, Kongi K, Cantuti L, Hanisch UW, Philips MA, Rossner MJ, Mann M*, Simons M* (2015) Cell-type and brain-region resolved mouse brain proteome. Nature Neurosci. 18:1819-1831 (co-corresponding author)
Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, Brückner BR, Alexopoulos I, Czopka T, Jung SY, Rhee JS, Janshoff A, Witke W, Schaap IA, Lyons DA, Simons M (2015) Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. Developmental Cell 27:139-51.
Snaidero N, Möbius W, Czopka T, Hekking L.H.P., Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons D.A., Nave K.A., Simons M. (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell 156:277-90.
Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B, Simons M (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319(5867):1244-7.