Munich Center for NeuroSciences - Brain and Mind
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Steffen Tiedt

PD Dr. Steffen Tiedt

GSN Alumnus WS 2017/2018, GSN full member

Responsibilities

Junior Research Group Leader

Contact

Institute for Stroke and Dementia Research (ISD)
Feodor-Lynen-Straße 17
D-81377 Munich

Phone: +49 (0)89 4400 46171

Website: http://tiedt-lab.isd-muc.de/

Further Information

Keywords: Stroke, Biomarker, Omics, Circadian

GSN Students: Vanessa Granja Burbano, Evan Hunter Stanton

Research description: We aim to identify circulating signatures that inform on the local and systemic effects of stroke and to explore the underlying molecular and pathophysiological mechanisms. Events in most organs including the local and systemic events (e.g. stress) related to acute stroke are captured by the circulating proteome and metabolome. In a bedside-to-bench-approach we apply profiling technologies on human samples to identify differentially regulated molecules and study their functional role in vitro and in vivo using experimental stroke models, transgenic animal models, different imaging modalities, and a broad range of biomolecular tools.

Selected publications:

Tiedt S, Buchan AM, Dichgans M, Lizasoain I, Moro MA, Lo EH. The neurovascular unit and systemic biology in stroke - implications for translation and treatment. Nat Rev Neurol. 2022 Oct;18(10):597-612.

Reidler P, Brehm A, Sporns PB, Burbano VG, Stueckelschweiger L, Broocks G, Liebig T, Psychogios MN, Ricke J, Dimitriadis K, Dichgans M, Kunz WG, Tiedt S. Circadian rhythm of ischaemic core progression in human stroke. J Neurol Neurosurg Psychiatry. 2021 May 26:jnnp-2021-326072.

Tiedt S, Brandmaier S, Kollmeier H, Duering M, Artati A, Adamski J, Klein M, Liebig T, Holdt LM, Teupser D, Wang-Sattler R, Schwedhelm E, Gieger C, Dichgans M. Circulating Metabolites Differentiate Acute Ischemic Stroke from Stroke Mimics. Ann Neurol. 2020 Oct;88(4):736-746.

Tiedt S, Duering M, Barro C, Kaya AG, Boeck J, Bode FJ, Klein M, Dorn F, Gesierich B, Kellert L, Ertl-Wagner B, Goertler MW, Petzold GC, Kuhle J, Wollenweber FA, Peters N, Dichgans M. Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke. Neurology 2018. Oct 2;91(14):e1338-e1347.

Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M. RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke. Circ Res. 2017 Sep 29;121(8):970-980.