Dr. Daniel Keeser

Brief research description: RG "Clinical Deep Phenotyping (CDP)" and RG "Neuromodulation and multimodal neuroimaging" Our research group at the University Hospital of LMU Munich focuses on Clinical Deep Phenotyping (CDP) and Multimodal Neuroimaging. We employ a comprehensive, multimodal strategy to meticulously characterize individuals affected by severe mental illnesses and neurological disorders. This approach integrates diverse neuroimaging modalities, including advanced magnetic resonance imaging (MRI) techniques such as structural imaging, resting-state functional MRI (rsfMRI), diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), arterial spin labeling (ASL), and dynamic contrast-enhanced MRI (DCE-MRI). Electroencephalography (EEG) is also utilized. Furthermore, we incorporate non-invasive brain stimulation methods, notably transcranial magnetic stimulation (TMS), frequently in conjunction with fMRI, while emphasizing rigorous methodological approaches. Our investigations concentrate on elucidating the neural underpinnings of conditions such as Schizophrenia Spectrum Disorders, Major Depressive Disorder, and Alzheimer's Disease. The primary objective is to deepen the understanding of the neurobiological basis of these conditions and to facilitate the development of personalized treatment strategies.

Keywords: multimodal neuroimaging, neuromodulation, neurophysiology, psychiatric diseases, MRI

Research methods: MRI, sMRI, rsfMRI, fMRI, DTI, ASL, DCE-MRI, EEG-fMRI, TMS-fMRI, tDCS-fMRI, OCT, ERG, genetics, multilevel research

Selected publications:

Multimodal Clustering Analysis of meta-analytically derived brain regions in Schizophrenia Spectrum Disorders. Korman M, Smith KM, Jiang T, Papiol S, Karsli B, Hasanaj G, Kallweit MS, Hisch A, Meisinger V, CDP Working Group, Moussiopoulou J, Yakimov V, Boudriot E, Ziller MJ, Zalesky A, Schmitt A, Falkai P, Wagner E, Raabe F, Roell L, Keeser D. medRxiv 2025.04.18.25325823; doi: https://doi.org/10.1101/2025.04.18.25325823

Roell L, Wunderlich S, Roell D, Raabe F, Wagner E, Shi Z, Schmitt A, Falkai P, Stoecklein S, Keeser D. How to measure functional connectivity using resting-state fMRI? A comprehensive empirical exploration of different connectivity metrics. Neuroimage. 2025 Apr 9;312:121195.

Moussiopoulou J, Yakimov V, Roell L, Rauchmann BS, Toth H, Melcher J, Jäger I, Lutz I, Kallweit MS, Papazov B, Boudriot E, Seelos K, Dehsarvi A, Campana M, Raabe F, Maurus I, Löhrs L, Brendel M, Stöcklein S, Falkai P, Hasan A, Group CW, Franzmeier N, Keeser D*, Wagner E*. Higher blood-brain barrier leakage in schizophrenia-spectrum disorders: A comparative dynamic contrast-enhanced magnetic resonance imaging study with healthy controls. Brain Behav Immun. 2025 Apr 5;128:256-265.

Chang KY, Tik M, Mizutani-Tiebel Y, Taylor P, van Hattem T, Falkai P, Padberg F, Bulubas L, Keeser D. Dose-Dependent Target Engagement of a Clinical Intermittent Theta Burst Stimulation Protocol: An Interleaved Transcranial Magnetic Stimulation-Functional Magnetic Resonance Imaging Study in Healthy People. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Aug 25:S2451-9022(24)00244-1.

Vural G, Soldini A, Padberg F, Karslı B, Zinchenko A, Goerigk S, Soutschek A, Mezger E, Stoecklein S, Bulubas L, Šušnjar A, Keeser D. Exploring the Effects of Prefrontal Transcranial Direct Current Stimulation on Brain Metabolites: A Concurrent tDCS-MRS Study. Hum Brain Mapp. 2024 Dec 15;45(18):e70097.