Responsibilities
Research Group Leader
Contact
Molecular Neurophysiology
Email:
antje.grosche@med.uni-muenchen.de
Website:
https://www.genom.physiol.med.uni-muenchen.de/research_gr/grosche_group/index.html
Further Information
Primary research focus: Biomedical Neuroscience
Second research focus: Molecular & Developmental Neuroscience
Third research focus: Cellular & Systems Neuroscience
Keywords: Retinal degeneration, Müller glia, neuroinflammation, gene therapy
Current or graduated GSN students: Patricia Hoffelner, Dr. Lew Kaplan, Dr. Anna-Monika Pfaller, Dr. Josef Biber
Selected publications:
Kaplan L, Drexler C, Pfaller AM, Brenna S, Wunderlich KA, Dimitracopoulos A, Merl-Pham J, Perez MT, Schlötzer-Schrehardt U, Enzmann V, Samardzija M, Puig B, Fuchs P, Franze K, Hauck SM, Grosche A. Retinal regions shape human and murine Müller cell proteome profile and functionality. Glia. 2022 Nov 5. doi: 10.1002/glia.24283.
Demais V, Pohl A, Wunderlich KA, Pfaller AM, Kaplan L, Barthélémy A, Dittrich R, Puig B, Giebel B, Hauck SM, Pfrieger FW, Grosche A. Release of VAMP5-positive extracellular vesicles by retinal Müller glia in vivo. J Extracell Vesicles. 2022 Sep;11(9):e12254. doi: 10.1002/jev2.12254.
Zauhar R, Biber J, Jabri Y, Kim M, Hu J, Kaplan L, Pfaller AM, Schäfer N, Enzmann V, Schlötzer-Schrehardt U, Straub T, Hauck SM, Gamlin PD, McFerrin MB, Messinger J, Strang CE, Curcio CA, Dana N, Pauly D, Grosche A, Li M, Stambolian D. As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues. Front Immunol. 2022 Jun 15;13:895519.
Pauly D, Agarwal D, Dana N, Schäfer N, Biber J, Wunderlich KA, Jabri Y, Straub T, Zhang NR, Gautam AK, Weber BHF, Hauck SM, Kim M, Curcio CA, Stambolian D, Li M, Grosche A. Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina. Cell Rep. 2019 Nov 26;29(9):2835-2848.e4.
Mages K, Grassmann F, Jägle H, Rupprecht R, Weber BHF, Hauck SM, Grosche A. The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia. J Neuroinflammation. 2019 Feb 18;16(1):43.