Prof. Dr. Jochen Herms

Primary research focus: Biomedical Neuroscience

Second research focus: Cellular & Systems Neuroscience

Third research focus: Behavioral & Cognitive Neuroscience

Research focus: Physiological function of proteins involved in Neurodegenerative diseases, synaptic failure in Neurodegenerative diseases like Alzheimer’s or Parkinson’s disease (AD,PD), long-term in vivo two-photon imaging of transgenic mice models of AD, neuronal calcium homeostasis in neurodegenerative diseases, high-throughput drug screens for AD and PD

Key words: Synaptic plasticity, Neurodegeneration, Alzheimers Disease, Parkinson Disease, In vivo 2Photon Imaging

GSN student

• Graduated: Dr. Kamran Honarnejad, Dr. Chengyu Zou, Dr. Viktoria Korzhova

Selected publications:

Herms, J.; Dorostkar, MM. (2016). Dendritic Spine Pathology in Neurodegenerative Diseases. Annu Rev Pathol. 11:221-50

Zou, C.; Shi,Y.; Ohli, J.; Schüller, U.; Dorostkar, MM.; Herms J. (2016). Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease. Acta Neuropathol. 131(2):235-46

Brendel, M.; Jaworska, A.; Herms, J.; Trambauer, J.; Rötzer, C.; Gildehaus, FJ.; Carlsen, J.; Cumming, P.; Bylund, J.; Luebbers, T.; Bartenstein, P.; Steiner, H.; Haass, C.; Baumann, K.; Rominger, A. (2015) Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment. Mol. Psychiatry, 20(10):1179-87

Willem, M.; Tahirovic, S.; Busche, MA.; Ovsepian, SV.; Chafai, M.; Kootar, S.; Hornburg, D.; Evans LD.; Moore, S.; Daria, A.; Hampel, H.,; Müller, V.; Giudici, C.; Nuscher, B.; Wenninger-Weinzierl, A.; Kremmer, E.; Heneka, MT.; Thal, DR.; Giedraitis, V.; Lannfelt, L.; Müller, U.; Livesey, FJ.; Meissner, F.; Herms, J.; Konnerth, A.; Marie, H.; Haass, C.(2015). η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 526(7573):443-7

Zou, C.; Montagna, E.; Shi, Y.; Peters, F.; Blazquez-Llorca, L.; Shi, S.; Filser, S.; Dorostkar, MM. Herms J. (2015). Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease. Acta Neuropathol. 129(6):909-20

Filser, S.; Ovsepian, SV.; Masana, M.; Blazquez-Llorca, L.; Brandt Elvang, A.; Volbracht, C.; Müller, MB.; Jung, CK.; Herms, J. (2015). Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions. Biol Psychiatry. 77(8):729-39

Ochs, S.; Dorostkar, M.; Aramuni, G.; Schön, C.; Filser, S.; Pöschl, J.; Kremer, A.; van Leuven, F.; Ovsepian, S.; Herms, J. (2015). Loss of neuronal GSK3 reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin. Mol Psychiatry, 20(4):482-9

Neuner, J.; Ovsepian, SV.; Dorostkar, M.; Filser, S.; Gupta, A.; Michalakis, S.; Biel, M.; Herms, J. (2014). Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nat Commun. 5:3915

Bittner, T.; Burgold, S.; Dorostkar, M.M.; Fuhrmann, M.; Wegenast-Braun, B.M.; Schmidt, B.; Kretzschmar, H.; Herms, J. (2012). Amyloid plaque formation precedes dendritic spine loss. Acta Neuropathol. 124(6):797-807, 2012

Fuhrmann, M.; Bittner, T.; Jung, C.K.E.; Burgold, S.; Page, R.M.; Mitteregger, G.; Haass, C.; LaFerla, F.M.; Kretzschmar, H.A.; Herms, J. (2010). Microglia CX3CR1 knockout prevents neuron loss in an Alzheimer's disease mouse model. Nature Neurosci. 13:411-413