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Martin Dichgans

Prof. Dr. Martin Dichgans

Regular member MCN, GSN Scientific Board member

Responsibilities

Director, Institute for Stroke and Dementia Research (ISD)

Contact

Institute for Stroke and Dementia Research (ISD)
Ludwig-Maximilians-University Munich, Medical Center
Feodor-Lynen-Straße 17
D-81377 Munich

Phone: +49 (0)89 4400 - 46019
Fax: +49 (0)89 4400 - 46010

Website: http://research.isd-muc.de/

Further Information

Research focus: Stroke, genetics of stroke, dementia; vascular dementia, neuroimaging, migraine

Key words: Clinical neuroscience, neurogenetics

GSN students

Curren: Manuel LehmJudit Gonzalez-Gallego, Marios Georgakis

Graduated: Dr. Steffen Tiedt

Selected publications:

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y,… [182 authors]…, Dichgans M. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics 2018. doi:10.1038/s41588-018-0058-3

Duering M, Finsterwalder S, Baykara E, …[4 authors] … Franzmeier N, Ewers M, Jouvent E, Biessels GJ, Schmidt R, de Leeuw FE, Pasternak O* Dichgans M* Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Alzheimer’s and Dementia (in press).

Tiedt S, Prestel P, Kautzky V, Düring M, Northoff B, Malik R, Klein M, Dorn F, Krohn K, Teupser D, Holdt L, Dichgans M. RNA -seq identifies circulating miR-125a-5p, miR-125b-5p and miR-143-3p as potential biomarkers for acute ischemic stroke. Circulation Research 2017 Sep 29;121(8):970-980. PMID: 28724745

Dichgans M, Leys D (2017) Vascular Cognitive Impairment. Circulation Research, 120(3):573-591.

Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, Dichgans M (2014) Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proc Natl Acad Sci USA 111(46):16496-16501. PMCID: PMC4246310

Wardlaw JM*, Smith EE*, Biessels GJ, …, [32 authors], …, Dichgans M*. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration: A united approach. Lancet Neurology 2013;12(8):822-38 (*equally contributing).

Wardlaw JM, Smith C, Dichgans M (2013) Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurology, 12(5):483-97. PMCID: PMC3836247

Freilinger T, … [39 authors] …, Palotie A*, Dichgans M*, van den Maagdenberg AMJM* for the International Headache Genetics Consortium. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nature Genetics (2012); 44(7):777-82 (*shared last-authorship). PMID: 22683712

Dichgans M, Markus HS, Salloway S, Verkkoniemi A, Moline M, Wang Q, Posner H, Chabriat H (2008) Donepezil in Patients with Subcortical Vascular Cognitive Impairment: a randomized double-blind trial in CADASIL Lancet Neurology, 7(4):310-318. PMID: 18296124

Dichgans M, Freilinger F, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, Ferrari M, Herzog J, van den Maagdenberg AM, Pusch M, Strom TM. (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine Lancet, 366(9483):371-377. PMID: 16054936