Munich Center for NeuroSciences - Brain and Mind
print

Links and Functions

Breadcrumb Navigation


Content
Martin Dichgans

Prof. Dr. Martin Dichgans

Regular member MCN, GSN Scientific Board member

Responsibilities

Director, Institute for Stroke and Dementia Research (ISD)

Contact

Institute for Stroke and Dementia Research (ISD)
Ludwig-Maximilians-University Munich, Medical Center
Feodor-Lynen-Straße 17
D-81377 Munich

Phone: +49 (0)89 4400 - 46019
Fax: +49 (0)89 4400 - 46010

Website: http://research.isd-muc.de/

Further Information

Research focus: Stroke, genetics of stroke, dementia; vascular dementia, neuroimaging, migraine

Key words: Clinical neuroscience, neurogenetics

GSN students

Selected publications:

2019

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke. Abraham G, Malik R, Yonova-Doing E, Salim A, Wang T, Danesh J, Butterworth AS, Howson JMM, Inouye M, Dichgans M. Nat Commun. 2019 Dec 20;10(1):5819.

Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide. Gladman JT, Corriveau RA, Debette S, Dichgans M, Greenberg SM, Sachdev PS, Wardlaw JM, Biessels GJ. Alzheimers Dement (N Y). 2019 Nov 19;5:789-796.

Stroke genetics: discovery, biology, and clinical applications. Dichgans M, Pulit SL, Rosand J.
Lancet Neurol. 2019 Jun;18(6):587-599.

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects. Gill D, Georgakis MK, Koskeridis F, Jiang L, Feng Q, Wei WQ, Theodoratou E, Elliott P, Denny JC, Malik R, Evangelou E, Dehghan A, Dichgans M, Tzoulaki I. Circulation. 2019 Jul 23;140(4):270-279.

Small vessel disease: mechanisms and clinical implications. Wardlaw JM, Smith C, Dichgans M.
Lancet Neurol. 2019 Jul;18(7):684-696.

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals. Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Peters A, Seshadri S, Myint PK, Nilsson J, de Lemos JA, Dichgans M. Circ Res. 2019 Sep 27;125(8):773-782.

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke. Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M. Circulation. 2019 Jan 8;139(2):256-268.

2018

Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Duering M, Finsterwalder S, Baykara E, Tuladhar AM, Gesierich B, Konieczny MJ, Malik R, Franzmeier N, Ewers M, Jouvent E, Biessels GJ, Schmidt R, de Leeuw FE, Pasternak O, Dichgans M. Alzheimers Dement. 2018 Jun;14(6):764-774.

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Malik R, (...), Dichgans M. Nat Genet. 2018 Apr;50(4):524-537.

CADASIL brain vessels show a HTRA1 loss-of-function profile. Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C. Acta Neuropathol. 2018 Jul;136(1):111-125.

Multi-ethnic genome-wide association study for atrial fibrillation. Roselli C, (...), Dichgans M, (...), Malik R, (...), Ellinor PT. Nat Genet. 2018 Jun 11;50(9):1225-1233.

Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke. Tiedt S, Duering M, Barro C, Kaya AG, Boeck J, Bode FJ, Klein M, Dorn F, Gesierich B, Kellert L, Ertl-Wagner B, Goertler MW, Petzold GC, Kuhle J, Wollenweber FA, Peters N, Dichgans M. Neurology. 2018 Oct 2;91(14):e1338-e1347.

Genome-wide meta-analysis identifies 3 novel loci associated with stroke. Malik R, Rannikmäe K, Traylor M, Georgakis MK, Sargurupremraj M, Markus HS, Hopewell JC, Debette S, Sudlow CLM, Dichgans M; MEGASTROKE consortium and the International Stroke Genetics Consortium. Ann Neurol. 2018 Dec;84(6):934-939.

Analysis of shared heritability in common disorders of the brain. Brainstorm Consortium, Anttila V, (...), Rainer Malik, ( ... ), Dichgans M; (...) Science. 2018 Jun 22;36

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants. Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M. BMJ. 2018 Oct 24;363:k4168.

 

Dichgans M, Markus HS, Salloway S, Verkkoniemi A, Moline M, Wang Q, Posner H, Chabriat H (2008) Donepezil in Patients with Subcortical Vascular Cognitive Impairment: a randomized double-blind trial in CADASIL Lancet Neurology, 7(4):310-318. PMID: 18296124

Dichgans M, Freilinger F, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, Ferrari M, Herzog J, van den Maagdenberg AM, Pusch M, Strom TM. (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine Lancet, 366(9483):371-377. PMID: 16054936