Prof. Dr. Mark Hübener

Keywords: Visual System, Plasticity, Visually Guided Behavior, Mouse

Brief research description: We are interested in the development, plasticity and function of the mammalian visual system. Using a combination of functional and structural imaging techniques, the lab studies how manipulations of visual input alter the response properties and the fine structure of neurons in mouse visual cortex. These studies are combined with behavioral experiments, in order to understand how learning of specific visual patterns or objects is reflected in altered neuronal responses and connectivity. In addition, the lab investigates the neuronal computations driving natural behaviors, like prey capture.

Current or graduated GSN students: Sandra Reinert, Danielle Paynter, Matthew McCann, Dr. Sabine Liebscher

Selected publications:

La Chioma A, Bonhoeffer T, Hübener M (2019). Area-specific mapping of binocular disparity across mouse visual cortex. Current Biology, in press. Falkner S*, Grade S*, Dimou L, Conzelmann K-K, Bonhoeffer T, Götz M*, Hübener M* (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539:248-253. https://doi.org/10.1038/nature20113

Rose T, Jaepel J, Hübener M, Bonhoeffer T (2016). Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex. Science 352:1319-1322. https://doi.org/10.1126/science.aad3358

Keller GB, Bonhoeffer T, Hübener M (2012). Sensorimotor mismatch signals in primary visual cortex of the behaving mouse. Neuron, 74: 809-815. https://doi.org/10.1016/j.neuron.2012.03.040

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009). Experience leaves a lasting structural trace in cortical circuits. Nature 457: 313-317. https://doi.org/10.1038/nature07487