Prof. Dr. Simon Jacob

Keywords: Neuronal mechanisms of higher cognitive functions, brain-computer-interfaces for disorders of cognition and mental health

Research methods: Controlled behavioral tasks, large-scale extracellular recordings in rodent models and human subjects, optogenetic manipulation of defined cell types and networks, neuroimaging and computational analysis

Brief research description: Cellular mechanisms of higher cognitive functions in humans and animal models, cortico-subcortical interactions during goal-directed behavior, neuromodulation of cognition

Current or graduated GSN students: Tobias Bernklau, Xiaoxiong Lin, Victoria Hohendorf, Xuanyu Wang, Hongbiao Chen, Stephen Guion (internship and research project), Xuanyu Wang (MSc)

Selected publications:

Jacob SN, Hähnke D and Nieder A. (2018) Structuring of abstract working memory content by fronto-parietal synchrony in primate cortex. Neuron, 99(3):588-597. doi: 10.1016/j.neuron.2018.07.025.

Jacob SN, Stalter M and Nieder A. (2016) Cell-type-specific modulation of targets and distractors by dopamine D1 receptors in primate prefrontal cortex. Nat Commun, doi: 10.1038/ncomms13218.

Ranganath A and Jacob SN. (2016) Doping the mind: dopaminergic regulation of prefrontal cortical cognition. Neuroscientist, 22(6):593-603. doi:10.1177/1073858415602850.

Ott T, Jacob SN, and Nieder A. (2014) Dopamine receptors differentially enhance rule coding in primate prefrontal cortex neurons. Neuron, 84(6):1317-28. doi: 10.1016/j.neuron.2014.11.012.

Jacob SN and Nieder A. (2014) Complementary roles for primate frontal and parietal cortex in guarding working memory from distractor stimuli. Neuron, 83(1):226-37. doi: 10.1016/j.neuron.2014.05.009.